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We identified histone H3 lysine 27 acetylation (H3K27Ac) as a modification upregulated in CRC, which had not been proven beforehand.Mutation of Tyr245 or Tyr305 in SET7/9 (Figure 4b ) alters its specificity from an H3 K4 mono-methylase to a tri- and di-methylase, respectively 16 , 21 , whereas an Ph...
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